作者
Ojus Sardana, Ravi Goyal, Onkar Bedi
发表日期
2021/8
来源
Inflammopharmacology
卷号
29
期号
4
页码范围
1061-1074
出版商
Springer International Publishing
简介
The liver acts as a manufacturing unit for the production of fetuin-A, which is essential for various physiological characteristics. Scientific research has shown that a moderate upward push in fetuin-A serum levels is associated with a confirmed non-alcoholic fatty liver disease (NAFLD) diagnosis. Fetuin-A modulation is associated with a number of pathophysiological variables that cause liver problems, including insulin receptor signaling deficiencies, adipocyte dysfunction, hepatic inflammation, fibrosis, triacylglycerol production, macrophage invasion, and TLR4 activation. The focus of the present review is on the various molecular pathways, and genetic relevance of mRNA expression of fetuin-A which is correlated with progression of NAFLD. The other major area of exploration in the present review is based on the new targets for the modulation of fetuin-A, like calorie restriction and novel pharmacological agents …
学术搜索中的文章
O Sardana, R Goyal, O Bedi - Inflammopharmacology, 2021