作者
Onkar Bedi, Niharika Srivastava, Davinder Parsad, Pawan Krishan
发表日期
2021/6/15
期刊
European Journal of Pharmacology
卷号
901
页码范围
174078
出版商
Elsevier
简介
The abnormal dietary life style leads to hyperlipidemia and insulin resistance with ectopic lipid accumulation and elevated levels of hepatic glucose development which are the underlying pathological characteristics of fatty liver diseases. The pharmacological inhibition of fatty acid synthase of de novo lipogenesis may regulate the dysfunctional lipid biotransformation and reverse the pathological state of diabetic liver injury. The three pharmacological interventions (PTS; Pterostilbene, ARB; Arbutin, PUR; Purpurin) were administered to manage the condition of diabetic liver injury against the high fat diet (HFD) + Streptozotocin (STZ) 30 mg/kg b.wt. rodent animal model to observe the effect of abnormal fatty acid synthesis. The qRT-PCR was used to evaluate the fatty acid synthase (FASN) expression which is independently allied with diabetes associated fatty liver disorders. To determine the therapeutic potential of …
学术搜索中的文章
O Bedi, N Srivastava, D Parsad, P Krishan - European Journal of Pharmacology, 2021