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Methods: The protocol was approved by the ethics committee (University of Erlangen) and according to the Helsinki Declaration and GCP. The prospective clinical study included 30 healthy subjects and 30 patients with mild or moderate traumatic brain injury (TBI). The Glasgow Coma Scale (GCS) characterized the severity of TBI. We examined 11 patients with moderate TBI (GCS 10-12) and 19 patients with mild TBI (GCS 13-15). The mean age was in healthy subjects 24+-2, in the patient group 43+-22 years. The healthy subjects were measured once, patients with mTBI were examined immediately after hospitalization, after 1 week and after 2 months.