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This paper describes a methodology to assess the evidence of human presence and human activities in the Brazilian Amazonia region using DMSP/OLS night-time satellite sensor imagery. It consists on exploring the potential of the sensor data for regional studies analysing the correlation between DMSP night-time light foci and population, and the correlation between DMSP night-time light foci and electrical power consumption. In the mosaic of DMSP/OLS night-time light imagery from September 1999, 248 towns were detected from a total of 749 municı́pios in Amazonia. It was found that the night-time light foci were related to human presence in the region, including urban settlements, mining, industries, and civil construction, observed in ancillary Landsat TM and JERS imagery data. The analysis considering only the state of Pará revealed a linear relation (R²=0.79) between urban population from the 1996 …