作者
K Marias, V Sakkalis, A Roniotis, C Farmaki, G Stamatakos, D Dionysiou, S Giatili, N Uzunoglou, N Graf, R Bohle, E Messe, PV Coveney, S Manos, S Wan, A Folarin, S Nagl, Philippe Büchler, Thibaut Bardyn, M Reyes, G Clapworthy, N Mcfarlane, E Liu, T Bily, M Balek, M Karasek, V Bednar, J Sabczynski, R Opfer, S Renisch, IC Carlsen
发表日期
2009
图书
World Congress on Medical Physics and Biomedical Engineering, September 7-12, 2009, Munich, Germany
页码范围
2124-2127
出版商
Springer, Berlin, Heidelberg
简介
The ContraCancrum project aims at developing a composite multilevel platform for simulating malignant tumor development and tumor and normal tissue response to therapeutic modalities and treatment schedules. The project aims at having an impact primarily in (a) the better under-standing of the natural phenomenon of cancer at different levels of biocomplexity and most importantly (b) the disease treatment optimization procedure in the patient’s individualized context by simulating the response to various therapeutic regimens. Fundamental biological mechanisms involved in tumor development and tumor and normal tissue treatment response such as metabolism, cell cycle, tissue mechanics, cell survival following treatment etc. are modeled also addressing stem cells in the context of both tumor and normal tissue behavior. The simulators exploit several discrete and continuous mathematics methods …
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K Marias, V Sakkalis, A Roniotis, C Farmaki… - World Congress on Medical Physics and Biomedical …, 2010