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The current global unpredictable market is characterized by increasing demand for highly customized products. To thrive in this scenario, it becomes essential to establish a closer interaction between product and manufacturing system, keeping the main focus on the client. Modular product design (MPD) is the best strategy to produce a large product variety. MPD’s configuration phase represents a key step for mass customization because it allows customers to be integrated into the value-creation process. Reconfigurable manufacturing systems (RMS) seem to be the most appropriate manufacturing system to manufacture mass-customized products due to their ability to be quickly reconfigured, adjusting their production capacity and functionality to fit new market demands. Aiming to integrate individual customer needs with product and manufacturing decisions, this paper proposes a new 0-1 nonlinear integer …