作者
Theresa W Guilbert, Wayne J Morgan, Robert S Zeiger, David T Mauger, Susan J Boehmer, Stanley J Szefler, Leonard B Bacharier, Robert F Lemanske Jr, Robert C Strunk, David B Allen, Gordon R Bloomberg, Gregory Heldt, Marzena Krawiec, Gary Larsen, Andrew H Liu, Vernon M Chinchilli, Christine A Sorkness, Lynn M Taussig, Fernando D Martinez
发表日期
2006/5/11
期刊
New England Journal of Medicine
卷号
354
期号
19
页码范围
1985-1997
出版商
Massachusetts Medical Society
简介
Background
It is unknown whether inhaled corticosteroids can modify the subsequent development of asthma in preschool children at high risk for asthma.
Methods
We randomly assigned 285 participants two or three years of age with a positive asthma predictive index to treatment with fluticasone propionate (at a dose of 88 μg twice daily) or masked placebo for two years, followed by a one-year period without study medication. The primary outcome was the proportion of episode-free days during the observation year.
Results
During the observation year, no significant differences were seen between the two groups in the proportion of episode-free days, the number of exacerbations, or lung function. During the treatment period, as compared with placebo use, use of the inhaled corticosteroid was associated with a greater proportion of episode-free days (P=0.006) and a lower rate of exacerbations (P<0.001) and …
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TW Guilbert, WJ Morgan, RS Zeiger, DT Mauger… - New England Journal of Medicine, 2006