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Comparative radiography is a forensic identification technique traditionally involving the manual comparison of ante-mortem and post-mortem radiographs, thus being time consuming and error prone. The main objective is to propose and validate a computer-aided comparative radiography paradigm based on the 3D bone scan-2D radiograph superimposition process of any bone or cavity. The proposal follows an image registration methodology to automatically search for the ante-mortem radiograph acquisition parameters from the forensic object’s silhouette considering occlusions. The underlying optimization problem is complex since a close initialization cannot be assumed and the image intensities are not reliable or not captured. Several experiments were performed to validate the method. First, we study its accuracy and robustness with synthetic images of clavicles, patellae and frontal sinuses. Second, we …