作者
VV Balaev, II Prokofev, AG Gabdoulkhakov, C Betzel, AA Lashkov
发表日期
2018/4/1
期刊
Structural Biology and Crystallization Communications
卷号
74
期号
4
页码范围
193-197
出版商
International Union of Crystallography
简介
Pyrimidine-nucleoside phosphorylase catalyzes the phosphorolytic cleavage of thymidine and uridine with equal activity. Investigation of this protein is essential for anticancer drug design. Here, the structure of this protein from Bacillus subtilis in complex with imidazole and sulfate is reported at 1.9 Å resolution, which is an improvement on the previously reported structure at 2.6 Å resolution. The localization and position of imidazole in the nucleoside-binding site reflects the possible binding of ligands that possess an imidazole ring.
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