作者
Elizabeth A Bobeck, Kimberly S Burgess, Taylor R Jarmes, Michelle L Piccione, Mark E Cook
发表日期
2012/4/13
期刊
Biochemical and biophysical research communications
卷号
420
期号
3
页码范围
666-670
出版商
Academic Press
简介
Phosphate in manure of monogastric animals pollutes the environment if improperly applied to soil. Strategies that reduce phosphate inputs into animal production systems reduce environmental pollution. Using a novel vaccine to fibroblast growth factor-23 (FGF-23), we induced neutralizing antibodies that reduced the phosphate requirement of growing chickens. Breeding hens were injected with a FGF-23 peptide (AFLPGMNP) conjugate. Antibody was passively transferred from hen to chick and chick response to deficient dietary phosphate intake was determined. Chicks without passive anti-FGF-23 antibody had a 43% and 21% reduction in blood phosphate and bone ash, respectively, when fed a phosphate deficient diet and compared to chicks fed a phosphate replete diet (P<0.05). Chicks with circulating anti-FGF-23 antibodies fed the phosphate deficient diet had plasma phosphate and bone ash that did not …
学术搜索中的文章
EA Bobeck, KS Burgess, TR Jarmes, ML Piccione… - Biochemical and biophysical research communications, 2012