作者
Kathryn M Hastie, Haoyang Li, Daniel Bedinger, Sharon L Schendel, S Moses Dennison, Kan Li, Vamseedhar Rayaprolu, Xiaoying Yu, Colin Mann, Michelle Zandonatti, Ruben Diaz Avalos, Dawid Zyla, Tierra Buck, Sean Hui, Kelly Shaffer, Chitra Hariharan, Jieyun Yin, Eduardo Olmedillas, Adrian Enriquez, Diptiben Parekh, Milite Abraha, Elizabeth Feeney, Gillian Q Horn, CoVIC-DB team 1, Yoann Aldon, Hanif Ali, Sanja Aracic, Ronald R Cobb, Ross S Federman, Joseph M Fernandez, Jacob Glanville, Robin Green, Gevorg Grigoryan, Ana G Lujan Hernandez, David D Ho, Kuan-Ying A Huang, John Ingraham, Weidong Jiang, Paul Kellam, Cheolmin Kim, Minsoo Kim, Hyeong Mi Kim, Chao Kong, Shelly J Krebs, Fei Lan, Guojun Lang, Sooyoung Lee, Cheuk Lun Leung, Junli Liu, Yanan Lu, Anna MacCamy, Andrew T McGuire, Anne L Palser, Terence H Rabbitts, Zahra Rikhtegaran Tehrani, Mohammad M Sajadi, Rogier W Sanders, Aaron K Sato, Liang Schweizer, Jimin Seo, Bingqing Shen, Jonne L Snitselaar, Leonidas Stamatatos, Yongcong Tan, Milan T Tomic, Marit J van Gils, Sawsan Youssef, Jian Yu, Tom Z Yuan, Qian Zhang, Bjoern Peters, Georgia D Tomaras, Timothy Germann, Erica Ollmann Saphire
发表日期
2021/10/22
期刊
Science
卷号
374
期号
6566
页码范围
472-478
出版商
American Association for the Advancement of Science
简介
Antibody-based therapeutics and vaccines are essential to combat COVID-19 morbidity and mortality after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Multiple mutations in SARS-CoV-2 that could impair antibody defenses propagated in human-to-human transmission and spillover or spillback events between humans and animals. To develop prevention and therapeutic strategies, we formed an international consortium to map the epitope landscape on the SARS-CoV-2 spike protein, defining and structurally illustrating seven receptor binding domain (RBD)–directed antibody communities with distinct footprints and competition profiles. Pseudovirion-based neutralization assays reveal spike mutations, individually and clustered together in variants, that affect antibody function among the communities. Key classes of RBD-targeted antibodies maintain neutralization activity against these …
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KM Hastie, H Li, D Bedinger, SL Schendel… - Science, 2021