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In the nuclear power industry, safety and reliability are of the utmost importance. Sensors and actuators are integral components in such systems, and potential faults may adversely impact system performance. It is therefore imperative to design a fault detection and diagnosis (FDD) system that achieves the highest standards of safety. This paper presents a machine learning-based fault detection and diagnosis (FDD) technique for actuators and sensors in a pressurized water reactor (PWR). In the proposed FDD framework, faults are first detected using a shallow neural network. Second, fault diagnosis is performed using 15 different classifiers provided in the MATLAB Classification Learner toolbox, including support vector machine (SVM), K-nearest neighbor (KNN), and ensemble. Several classifiers were found to provide superior classification performance, including medium KNN, cubic KNN, cosine KNN …