作者
Devon L Graham, Heather H Durai, Taylor S Trammell, Brenda L Noble, Douglas P Mortlock, Aurelio Galli, Gregg D Stanwood
发表日期
2020/10
期刊
Journal of Comparative Neurology
卷号
528
期号
14
页码范围
2445-2470
出版商
John Wiley & Sons, Inc.
简介
Glucagon‐like peptide‐1 (GLP‐1) is an incretin hormone with a number of functions to maintain energy homeostasis and contribute to motivated behavior, both peripherally and within the central nervous system (CNS). These functions, which include insulin secretion, gastric emptying, satiety, and the hedonic aspects of food and drug intake, are primarily mediated through stimulation of the GLP‐1 receptor. While this receptor plays an important role in a variety of physiological outcomes, data regarding its CNS expression has been primarily limited to regional receptor binding and single‐label transcript expression studies. We thus developed a bacterial artificial chromosome transgenic mouse, in which expression of a red fluorescent protein (mApple) is driven by the GLP‐1R promoter. Using this reporter mouse, we characterized the regional and cellular expression patterns of GLP‐1R expressing cells in the CNS …
引用总数
202020212022202320243161678
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