作者
NR Wray, ML Pergadia, DHR Blackwood, BWJH Penninx, SD Gordon, DR Nyholt, Stephan Ripke, DJ MacIntyre, KA McGhee, AW Maclean, JH Smit, JJ Hottenga, G Willemsen, CM Middeldorp, EJC De Geus, CM Lewis, P McGuffin, IB Hickie, EJCG Van den Oord, JZ Liu, S Macgregor, BP McEvoy, EM Byrne, SE Medland, Dixie J Statham, AK Henders, AC Heath, GW Montgomery, NG Martin, DI Boomsma, PAF Madden, PF Sullivan
发表日期
2012/1
期刊
Molecular psychiatry
卷号
17
期号
1
页码范围
36-48
出版商
Nature Publishing Group
简介
Major depressive disorder (MDD) is a common complex disorder with a partly genetic etiology. We conducted a genome-wide association study of the MDD2000+ sample (2431 cases, 3673 screened controls and> 1 M imputed single-nucleotide polymorphisms (SNPs)). No SNPs achieved genome-wide significance either in the MDD2000+ study, or in meta-analysis with two other studies totaling 5763 cases and 6901 controls. These results imply that common variants of intermediate or large effect do not have main effects in the genetic architecture of MDD. Suggestive but notable results were (a) gene-based tests suggesting roles for adenylate cyclase 3 (ADCY3, 2p23. 3) and galanin (GAL, 11q13. 3); published functional evidence relates both of these to MDD and serotonergic signaling;(b) support for the bipolar disorder risk variant SNP rs1006737 in CACNA1C (P= 0.020, odds ratio= 1.10); and (c) lack of support …
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NR Wray, ML Pergadia, DHR Blackwood, B Penninx… - Molecular psychiatry, 2012