作者
Susan B Kesmodel, Giorgos C Karakousis, Jeffrey D Botbyl, Robert J Canter, Robert T Lewis, Peter M Wahl, Kyla P Terhune, Abass Alavi, David E Elder, Michael E Ming, DuPont Guerry, Phyllis A Gimotty, Douglas L Fraker, Brian J Czerniecki, Francis R Spitz
发表日期
2005/6/1
期刊
Annals of surgical oncology
卷号
12
期号
6
页码范围
449-458
出版商
Springer-Verlag
简介
Background
Lymphatic mapping and sentinel lymphadenectomy (LM/SL) provide important prognostic information for patients with early-stage melanoma. Although the use of this technique in patients with thin melanomas (≤1.00 mm) is not routine, risk factors that may predict sentinel lymph node (SLN) positivity in this patient population are under investigation. We sought to determine whether mitotic rate (MR) is associated with SLN positivity in thin-melanoma patients and, therefore, whether it may be used to risk-stratify and select patients for LM/SL.
Methods
Clinical and histopathologic variables were reviewed for 181 patients with thin melanomas who underwent LM/SL from January 1996 through January 2004. Univariate and multivariate logistic regression analyses were performed to identify factors associated with SLN positivity. Risk groups were …
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SB Kesmodel, GC Karakousis, JD Botbyl, RJ Canter… - Annals of surgical oncology, 2005