作者
Sarah M Merrill, Sarah R Moore, Nicole Gladish, Gerald F Giesbrecht, Deborah Dewey, Chaini Konwar, Julia L MacIssac, Michael S Kobor, Nicole L Letourneau
发表日期
2021/9
期刊
Developmental Psychobiology
卷号
63
期号
6
页码范围
e22174
简介
Adverse childhood experiences (ACEs), or cumulative childhood stress exposures, such as abuse, neglect, and household dysfunction, predict later health problems in both the exposed individuals and their offspring. One potential explanation suggests exposure to early adversity predicts epigenetic modification, especially DNA methylation (DNAm), linked to later health. Stress experienced preconception by mothers may associate with DNAm in the next generation. We hypothesized that fathers’ exposure to ACEs also associates with their offspring DNAm, which, to our knowledge, has not been previously explored. An epigenome‐wide association study (EWAS) of blood DNAm (n = 45) from 3‐month‐old infants was regressed onto fathers’ retrospective ACEs at multiple Cytosine‐phosphate‐Guanosine (CpG) sites to discover associations. This accounted for infants’ sex, age, ethnicity, cell type proportion, and …
引用总数
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SM Merrill, SR Moore, N Gladish, GF Giesbrecht… - Developmental Psychobiology, 2021