作者
Jennifer M Robertson, Megan MacLeod, Vanessa S Marsden, John W Kappler, Philippa Marrack
发表日期
2006/6
来源
Immunological reviews
卷号
211
期号
1
页码范围
49-57
出版商
Blackwell Publishing Ltd
简介
Memory T cells are thought to have several properties that distinguish them from their naïve precursors. They are found in parts of the body that rarely house naïve cells, they respond to antigen with faster proliferation and more rapid progression to effector function, they are less sensitive to the absence of their selecting major histocompatibility complex (MHC), and, above all, they are long lived. Here we show that this last property may not be universal. Some CD4+ T cells that have surface proteins characteristic of memory cells have the same half‐life in vivo as naïve cells. The description of these cells as memory cells therefore depends on our definition of the word ‘memory’.
引用总数
20072008200920102011201220132014201520162017201820192020202120228169752211
学术搜索中的文章
JM Robertson, M MacLeod, VS Marsden, JW Kappler… - Immunological reviews, 2006