作者
Ying Gao, Zheng Zhong, Dengwei Zhang, Jian Zhang, Yong-Xin Li
发表日期
2024/5/24
期刊
Microbiome
卷号
12
期号
1
页码范围
94
出版商
BioMed Central
简介
Background
Microbial secondary metabolites play a crucial role in the intricate interactions within the natural environment. Among these metabolites, ribosomally synthesized and post-translationally modified peptides (RiPPs) are becoming a promising source of therapeutic agents due to their structural diversity and functional versatility. However, their biosynthetic capacity and ecological functions remain largely underexplored.
Results
Here, we aim to explore the biosynthetic profile of RiPPs and their potential roles in the interactions between microbes and viruses in the ocean, which encompasses a vast diversity of unique biomes that are rich in interactions and remains chemically underexplored. We first developed TrRiPP to identify RiPPs from ocean metagenomes, a deep learning method that detects RiPP precursors in a hallmark gene-independent manner to overcome the limitations of classic methods in …
学术搜索中的文章
Y Gao, Z Zhong, D Zhang, J Zhang, YX Li - Microbiome, 2024