作者
Dengwei Zhang, Si Zhou, Ziheng Zhou, Xiaosen Jiang, Dongsheng Chen, Hai-Xi Sun, Jie Huang, Shoufang Qu, Songchen Yang, Ying Gu, Xiuqing Zhang, Xin Jin, Ya Gao, Yue Shen, Fang Chen
发表日期
2021/12
期刊
BMC Medical Genomics
卷号
14
页码范围
1-10
出版商
BioMed Central
简介
Background
Birth defects pose a major challenge to infant health. Thus far, however, the causes of most birth defects remain cryptic. Over the past few decades, considerable effort has been expended on disclosing the underlying mechanisms related to birth defects, yielding myriad treatises and data. To meet the increasing requirements for data resources, we developed a freely accessible birth defect multi-omics database (BDdb, http://t21omics.cngb.org ) consisting of multi-omics data and potential disease biomarkers.
Results
In total, omics datasets from 136 Gene Expression Omnibus (GEO) Series records, including 5245 samples, as well as 869 biomarkers of 22 birth defects in six different species, were integrated into the BDdb. The database provides a user-friendly interface for searching, browsing, and downloading …
学术搜索中的文章
D Zhang, S Zhou, Z Zhou, X Jiang, D Chen, HX Sun… - BMC Medical Genomics, 2021