作者
Ariel U Spencer, Andreea Neaga, Brady West, Jared Safran, Pamela Brown, Imad Btaiche, Barbara Kuzma-O'Reilly, Daniel H Teitelbaum
发表日期
2005/9/1
来源
Annals of surgery
卷号
242
期号
3
页码范围
403-412
出版商
LWW
简介
Objective:
To determine predictors of survival and of weaning off parenteral nutrition (PN) in pediatric short bowel syndrome (SBS) patients.
Summary Background Data:
Pediatric SBS carries extensive morbidity and high mortality, but factors believed to predict survival or weaning from PN have been based on limited studies. This study reviews outcomes of a large number of SBS infants and identifies predictors of success.
Methods:
Multivariate Cox proportional hazards analysis was conducted on 80 pediatric SBS patients. Primary outcome was survival; secondary outcome was ability to wean off PN. Nonsignificant covariates were eliminated. P< 0.05 was considered significant.
Results:
Over a mean of 5.1 years of follow-up, survival was 58 of 80 (72.5%) and 51 weaned off PN (63.8%). Cholestasis (conjugated bilirubin≥ 2.5 mg/dL) was the strongest predictor of mortality (relative risk [RR] 22.7, P= 0.005). Although …
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AU Spencer, A Neaga, B West, J Safran, P Brown… - Annals of surgery, 2005