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Artificial intelligence (AI) is a powerful tool that is commonly applied in engineering multi-disciplines owing to its functionality to resolve real-world problems where deterministic solutions are arduous to achieve. Revolution in water treatment and desalination process automation has been emerging recently. Several challenges are present in the water sector related to data structuring and smart water services through which AI would have great potential once those issues are addressed. The distinctive tools of AI, mainly; artificial neural networks (ANNs), as a regression model, and genetic algorithm (GA), as one of the global optimization techniques, have been immensely applied in desalination and water treatment for multi-purpose applications. Modelling desalination and water treatment processes and optimizing the operating condition are few among the many applications. In the current review, paramount …