作者
Ian C Welsh, Aaron Hagge-Greenberg, Timothy P O’Brien
发表日期
2007/9/1
期刊
Mechanisms of development
卷号
124
期号
9-10
页码范围
746-761
出版商
Elsevier
简介
The formation of the palate involves the coordinated outgrowth, elevation and midline fusion of bilateral shelves leading to the separation of the oral and nasal cavities. Reciprocal signaling between adjacent fields of epithelial and mesenchymal cells directs palatal shelf growth and morphogenesis. Loss of function mutations in genes encoding FGF ligands and receptors have demonstrated a critical role for FGF signaling in mediating these epithelial–mesenchymal interactions. The Sprouty family of genes encode modulators of FGF signaling. We have established that mice carrying a deletion that removes the FGF signaling antagonist Spry2 have cleft palate. We show that excessive cell proliferation in the Spry2-deficient palate is accompanied by the abnormal progression of shape changes and movements required for medially directed shelf outgrowth and midline contact. Expression of the FGF responsive …
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IC Welsh, A Hagge-Greenberg, TP O'Brien - Mechanisms of development, 2007