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Designing special heterogeneous structures has been proven to be an effective strategy for breaking the trade-off between strength and ductility. In this work, we drew inspiration from the architectural integrity and mechanical ingenuity of the mortise-and-tenon joint, a hallmark of traditional craftsmanship, to engineer a novel mechanically interlocked network (MIN) within a 3D printed high-entropy alloy (HEA). The sub-grains crosslink not only mimics the joint in structure, but also reproduces its function in modifying the mechanical properties of the MIN. The MIN structure provides the excellent structural stability and disperses the stress concentration at the grain boundary during the deformation process, which thus avoids the fracture failure caused by the crack propagation. The alloy's remarkable performance, characterized by a tensile strength of approximately 1152 MPa and an elongation of 28%, is attributed to a …