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Long-combination vehicles (LCVs) have significant potential to increase economic productivity for shippers and carriers by decreasing the number of truck trips, thus reducing costs. However, size and weight regulations, triggered by safety concerns and, in some cases, infrastructure investment concerns, have prevented large-scale adoption of such vehicles. Information on actual crash performance is needed. To this end, this work uses standard and heteroskedastic ordered probit models, along with the United States’ Large Truck Crash Causation Study, General Estimates System, and Vehicle Inventory and Use Survey data sets, to study the impact of vehicle, occupant, driver, and environmental characteristics on injury outcomes for those involved in crashes with heavy-duty trucks. Results suggest that the likelihood of fatalities and severe injury is estimated to rise with the number of trailers, but fall with the truck …