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Major Depressive Disorder (MDD) is one of the leading causes of disability worldwide. Prediction of response to Selective Serotonin Reuptake Inhibitors (SSRIs) antidepressants in patients with MDD is necessary for preventing side effects of mistreatment. In this study, a deep Transfer Learning (TL) strategy based on powerful pre-trained convolutional neural networks (CNNs) in the big data datasets is developed for classification of Responders and Non-Responders (R/NR) to SSRI antidepressants, using 19-channel Electro-encephalography (EEG) signal acquired from 30 MDD patients in the resting state. Multiple time–frequency images are obtained from each EEG channel using Continuous Wavelet Transform (CWT) for feeding into pre-trained CNN models that are VGG16, Xception, DenseNet121, MobileNetV2 and InceptionResNetV2. Our plan is to adapt and fine-tune the weights of networks to the target task …