作者
Xin Chen, Jim Graham, Mohammad A Dabbah, Ioannis N Petropoulos, Georgios Ponirakis, Omar Asghar, Uazman Alam, Andrew Marshall, Hassan Fadavi, Maryam Ferdousi, Shazli Azmi, Mitra Tavakoli, Nathan Efron, Maria Jeziorska, Rayaz A Malik
发表日期
2015/6/1
期刊
Diabetes care
卷号
38
期号
6
页码范围
1138-1144
出版商
American Diabetes Association
简介
OBJECTIVE
Quantitative assessment of small fiber damage is key to the early diagnosis and assessment of progression or regression of diabetic sensorimotor polyneuropathy (DSPN). Intraepidermal nerve fiber density (IENFD) is the current gold standard, but corneal confocal microscopy (CCM), an in vivo ophthalmic imaging modality, has the potential to be a noninvasive and objective image biomarker for identifying small fiber damage. The purpose of this study was to determine the diagnostic performance of CCM and IENFD by using the current guidelines as the reference standard.
RESEARCH DESIGN AND METHODS
Eighty-nine subjects (26 control subjects and 63 patients with type 1 diabetes), with and without DSPN, underwent a detailed assessment of neuropathy, including CCM and skin biopsy.
RESULTS
Manual and automated corneal nerve fiber …
学术搜索中的文章
X Chen, J Graham, MA Dabbah, IN Petropoulos… - Diabetes care, 2015