作者
Shaohua Lu, Hui Kong, Yingyong Hou, Di Ge, Wei Huang, Jiaxian Ou, Dawei Yang, Li Zhang, Guoming Wu, Yong Song, Xiaoju Zhang, Changwen Zhai, Qun Wang, Hongguang Zhu, Ying Wu, Chunxue Bai
发表日期
2018/9/1
期刊
Lung Cancer
卷号
123
页码范围
44-51
出版商
Elsevier
简介
Objectives
Early and accurate diagnosis of lung cancer is crucial for effective treatment. This study aimed to identify plasma microRNAs for diagnosis of lung cancer and for further discrimination of small cell lung cancer (SCLC) from non-small cell lung cancer (NSCLC).
Materials and methods
Plasma microRNA expression was investigated using three independent cohorts including 1132 participants recruited between October 2008 and September 2014 from five medical centers. The subjects were healthy individuals and patients with NSCLC or SCLC. Microarrays were used to screen 723 human microRNAs in 106 plasma samples for candidate selection. Quantitative reverse-transcriptase PCR was applied to evaluate the expression of selected microRNAs. Two logistic regression models were constructed based on a training cohort (n = 565) and then validated using an independent cohort (n = 461). The area …
学术搜索中的文章
S Lu, H Kong, Y Hou, D Ge, W Huang, J Ou, D Yang… - Lung Cancer, 2018