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A new parallel label‐free isolation platform for isolating cancer cells (>10 µm) from biological samples using an array of acoustic microstreaming traps is demonstrated. The new microstreaming trapping platform offers high isolation efficiency and treatment in spiked diluted (1:2) blood samples without labeling, extra processing steps or sheath flows (common to other label‐free cell‐separation methods), hence, simplifying the microfluidic set‐up and operation. The versatility of this label‐free method is illustrated by the size‐dependent isolation of synthetic colloids and by three different models of breast cancer cells, showing a remarkably high isolation efficiency (95 ± 5%), being ≈100% for MCF‐7. Extensive experimental data and theoretical simulations confirm that the local acoustic microstreaming produced by the micropillar trap can discriminate and isolate microparticles based solely on their size. Moreover, the …