作者
Fatemeh Mashhadiabbas, Faranak Mahjour, Seyyed Babak Mahjour, Forouzandeh Fereidooni, Fatemeh Sadat Hosseini
发表日期
2012/8/1
期刊
Oral surgery, oral medicine, oral pathology and oral radiology
卷号
114
期号
2
页码范围
240-250
出版商
Mosby
简介
OBJECTIVES
The aim of this study was to immunohistochemically evaluate the expression of matrix metalloproteinase (MMP)-1, MMP- 2, tissue inhibitor of metalloproteinase (TIMP)-1, TIMP-2, and podoplanin in oral squamous cell carcinoma (OSCC). Immunohistochemical staining of podoplanin-positive lymphatic vessel density (LVD) was also assessed.
STUDY DESIGN
Forty cases of OSCC were analyzed by immunohistochemistry.
RESULTS
MMP-2, MMP-10, TIMP-1, TIMP-2, and podoplanin were detected in each of the 40 OSCC cases. The expression of MMP-2 was significantly correlated with histologic grade. The expression of podoplanin was positively correlated with gender and negatively correlated with tumor size. A significant positive correlation was also detected between LVD and the presence of lymph node metastases, gender, age, and diameter of the lymph node (if involved), as well as histologic …
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F Mashhadiabbas, F Mahjour, SB Mahjour… - Oral surgery, oral medicine, oral pathology and oral …, 2012