作者
Nikolaos Kartalis, Georgios C Manikis, Louiza Loizou, Nils Albiin, Frank G Zöllner, Marco Del Chiaro, Kostas Marias, Nikolaos Papanikolaou
发表日期
2016/1/1
来源
European journal of radiology open
卷号
3
页码范围
79-85
出版商
Elsevier
简介
Objectives
To compare two Gaussian diffusion-weighted MRI (DWI) models including mono-exponential and bi-exponential, with the non-Gaussian kurtosis model in patients with pancreatic ductal adenocarcinoma.
Materials and methods
After written informed consent, 15 consecutive patients with pancreatic ductal adenocarcinoma underwent free-breathing DWI (1.5T, b-values: 0, 50, 150, 200, 300, 600 and 1000 s/mm2). Mean values of DWI-derived metrics ADC, D, D*, f, K and DK were calculated from multiple regions of interest in all tumours and non-tumorous parenchyma and compared. Area under the curve was determined for all metrics.
Results
Mean ADC and DK showed significant differences between tumours and non-tumorous parenchyma (both P < 0.001). Area under the curve for ADC, D, D*, f, K, and DK were 0.77, 0.52, 0.53, 0.62, 0.42, and 0.84, respectively.
Conclusion
ADC and DK could differentiate …
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N Kartalis, GC Manikis, L Loizou, N Albiin, FG Zöllner… - European journal of radiology open, 2016