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There is great need for high intensity proton beams from compact particle accelerators in particle physics, medical isotope production, and materials-and energy-research. To address this need, we present, for the first time, a design for a compact isochronous cyclotron that will be able to deliver 10 mA of 60 MeV protons—an order of magnitude higher than on-market compact cyclotrons and a factor four higher than research machines. A key breakthrough is that vortex motion is incorporated in the design of a cyclotron, leading to clean extraction. Beam losses on the septa of the electrostatic extraction channels stay below 120 W (40% below the required safety limit), while maintaining good beam quality. We present a set of highly accurate particle-in-cell simulations, and an uncertainty quantification of select beam input parameters using machine learning, showing the robustness of the design. This design can be …