作者
Timothy A Bates, Savannah K McBride, Bradie Winders, Devin Schoen, Lydie Trautmann, Marcel E Curlin, Fikadu G Tafesse
发表日期
2022/1/11
期刊
Jama
卷号
327
期号
2
页码范围
179-181
出版商
American Medical Association
简介
Methods| Fully vaccinated health care workers subsequently diagnosed with SARS-CoV-2 breakthrough infection based on a positive polymerase chain reaction (PCR) test result were sequentially recruited at the Oregon Health & Science University between January 31, 2021, and August 18, 2021. Only those with no history of previous infection whose test results were negative for nucleocapsid antibodies were included. Controls were fully vaccinated individuals without a breakthrough infection matched on sex, age, time between vaccine doses, and time between sample collection and most recent antigen exposure (PCR confirmation for those with breakthrough infection and final vaccine dose for controls). Fulllength viral genomic sequencing was used to determine SARS-CoV-2 variant identity. Enzyme-linked immunosorbent assays were used to determine serum dilution titers with a 50% effective concentration …
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TA Bates, SK McBride, B Winders, D Schoen… - Jama, 2022