作者
Brad H Rovin, Jonathan Barratt, Hiddo JL Heerspink, Charles E Alpers, Stewart Bieler, Dong-Wan Chae, Ulysses A Diva, Jürgen Floege, Loreto Gesualdo, Jula K Inrig, Donald E Kohan, Radko Komers, Laura Ann Kooienga, Richard Lafayette, Bart Maes, Robert Małecki, Alex Mercer, Irene L Noronha, Se Won Oh, Chen Au Peh, Manuel Praga, Priscila Preciado, Jai Radhakrishnan, Michelle N Rheault, William E Rote, Sydney CW Tang, Vladimir Tesar, Howard Trachtman, Hernán Trimarchi, James A Tumlin, Muh Geot Wong, Vlado Perkovic, Isabella Abbasciano, Catarina Abrantes, Simone Accarino, Sharon Adler, Annika Adoberg, Rouzbeh Afsari, Syeda Ahmad, Jafar Ahmed, Wooin Ahn, Bamidele Ajayi, Dariusz Aksamit, Saif Al Chalabi, Eric Alamartine, Bassam Alchi, Mohammad Ali, Roberta Aliotta, Salem Almaani, Catarina Almeida, Edgar Almeida, Francisco de la Prada Alvarez, Patricia Alves, Francesca Annese, Gerald Appel, Alberto Ortiz Arduan, Maria Arena, Marta Calvo Arevalo, Dariush Arfaania, Carlos Arias, Emma Calatayud Aristoy, Egle Asakiene, Sarah Ashley, Ali Assefi, Alba Atenza, Asta Auerbach, Hanna Augustyniak-Bartosik, Monroy Avella, Jonathan Ayling-Smith, Isabelle Ayoub, Christine Ayvazyan, Rocco Baccaro, Asha Bailey, Bruce Baker, Saravanan Balamuthusamy, Jose Ballarin, Rui Barata, Jerko Barbic, Dunja Barisic, Jose Carlos de Jesus Barreto, Clara Barrios, Mirco Belingheri, Anna Benesova, Ana Avila Bernabeu, Wanja Bernhardt, Shamik Bhadra, Luigi Biancone, Anne Blanchard, Elena Boaglio, Davide Bolignano, Andrew Bomback, Gustavo Andres Useche Bonilla, Monica Bordoli, Bhadran Bose, Neil Boudville, Donald Brandon, Karen Brown, Christian Broyet, Thomas Bucknall, Alexandre Buffet, Inga Arune Bumblyte, Manuel Burdese, Natalia Allende Burgos, Laure Burguet, Stephane Burtey, Martin Busch, Figen Cakiroglu, Victoria Campbell, Pietro Canetta, Flavia Capaccio, Juan Carbonell, Filipa Cardoso, Clara Garcia Carro, Robert Carroll, Pierre-Louis Carron, Nazareno Carullo, Matthias Cassia, Dawn Caster, Belen Vizcaino Castillo, Davide Catucci, Andrea Cavalli, Aron Chakera, Doris Chan, Gary Chi Wang Chan, Anthony Ting Pong Chan, Lai Wan Chan, Jae Hyun Chang, Ming-Shan Chang, Fiona Chapman, Chaim Charytan, Asghar Chaudhry, Melissa Cheetham, Cheng-Hsu Chen, Hsin-Yu Chen, Chien-Liang Chen, Hung-Yuan Chen, Hung-Chun Chen, Leila Chenine, Siu Fai Cheung, Chee Kay Cheung, Noemie Chiche-Jourde, Hsien-Fu Chiu, Yen-Ling Chiu, Yi-Wen Chiu, Ian Chiu, Hoon Young Choi, Kang-Ju Chou, Paramit Chowdhury, Pradip Chowdhury, Constantina Chrysochou
发表日期
2023/12/2
期刊
The Lancet
卷号
402
期号
10417
页码范围
2077-2090
出版商
Elsevier
简介
Background
Sparsentan, a novel, non-immunosuppressive, single-molecule, dual endothelin angiotensin receptor antagonist, significantly reduced proteinuria versus irbesartan, an angiotensin II receptor blocker, at 36 weeks (primary endpoint) in patients with immunoglobulin A nephropathy in the phase 3 PROTECT trial's previously reported interim analysis. Here, we report kidney function and outcomes over 110 weeks from the double-blind final analysis.
Methods
PROTECT, a double-blind, randomised, active-controlled, phase 3 study, was done across 134 clinical practice sites in 18 countries throughout the Americas, Asia, and Europe. Patients aged 18 years or older with biopsy-proven primary IgA nephropathy and proteinuria of at least 1·0 g per day despite maximised renin–angiotensin system inhibition for at least 12 weeks were randomly assigned (1:1) to receive sparsentan (target dose 400 mg oral …
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BH Rovin, J Barratt, HJL Heerspink, CE Alpers, S Bieler… - The Lancet, 2023