查看文章

Large vein endothelium plays important roles in clinical diseases such as chronic venous disease (CVD) and thrombosis; thus to characterize CVD vein endothelial cells (VEC) has a strategic role in identifying specific therapeutic targets. On these bases we evaluated the effect of the natural anti‐inflammatory compounds α‐Lipoic acid and Ginkgoselect phytosome on cytokines/chemokines released by CVD patient‐derived VEC. For this purpose, we characterized the levels of a panel of cytokines/chemokines (n = 31) in CVD patients’ plasma compared to healthy controls and their release by VEC purified from the same patients, in unstimulated and TNF‐α stimulated conditions. Among the cytokines/chemokines released by VEC, which recapitulated the systemic profile (IL‐8, TNF‐α, GM‐CSF, INF‐α2, G‐CSF, MIP‐1β, VEGF, EGF, Eotaxin, MCP‐1, CXCL10, PDGF, and RANTES), we identified those targeted by ex …