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Skin burn induced by thermal radiation or heat source is one of the common but severe, injuries in firefighting and some industry work exposed to intensive radiation. In this article, a multi-layer skin model on heat and mass transfer is presented article to investigate the effects of blood perfusion, water diffusion, and vaporization on tissue temperature and skin burn after removing the heat source. The numerical results of the model are in good agreement with previous experimental results. A parametric study is carried out to investigate the effects of skin geometrical and thermal parameters, and initial tissue temperature on skin temperature distribution and burn injuries after the removal of the heat source. The results show two-sided effects on tissue temperature, i.e., heat loss due to water vaporization and water diffusion can cool the epidermis; however, blood perfusion and water diffusion heat the subcutaneous …