作者
Rungtiwa Nutalai, Daming Zhou, Aekkachai Tuekprakhon, Helen M Ginn, Piyada Supasa, Chang Liu, Jiandong Huo, Alexander J Mentzer, Helen ME Duyvesteyn, Aiste Dijokaite-Guraliuc, Donal Skelly, Thomas G Ritter, Ali Amini, Sagida Bibi, Sandra Adele, Sile Ann Johnson, Bede Constantinides, Hermione Webster, Nigel Temperton, Paul Klenerman, Eleanor Barnes, Susanna J Dunachie, Derrick Crook, Andrew J Pollard, Teresa Lambe, Philip Goulder, Neil G Paterson, Mark A Williams, David R Hall, Juthathip Mongkolsapaya, Elizabeth E Fry, Wanwisa Dejnirattisai, Jingshan Ren, David I Stuart, Gavin R Screaton
发表日期
2022/6/9
期刊
Cell
卷号
185
期号
12
页码范围
2116-2131. e18
出版商
Cell Press
简介
Highly transmissible Omicron variants of SARS-CoV-2 currently dominate globally. Here, we compare neutralization of Omicron BA.1, BA.1.1, and BA.2. BA.2 RBD has slightly higher ACE2 affinity than BA.1 and slightly reduced neutralization by vaccine serum, possibly associated with its increased transmissibility. Neutralization differences between sub-lineages for mAbs (including therapeutics) mostly arise from variation in residues bordering the ACE2 binding site; however, more distant mutations S371F (BA.2) and R346K (BA.1.1) markedly reduce neutralization by therapeutic antibody Vir-S309. In-depth structure-and-function analyses of 27 potent RBD-binding mAbs isolated from vaccinated volunteers following breakthrough Omicron-BA.1 infection reveals that they are focused in two main clusters within the RBD, with potent right-shoulder antibodies showing increased prevalence. Selection and somatic …
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R Nutalai, D Zhou, A Tuekprakhon, HM Ginn, P Supasa… - Cell, 2022