作者
Katharina Röltgen, Sandra CA Nielsen, Oscar Silva, Sheren F Younes, Maxim Zaslavsky, Cristina Costales, Fan Yang, Oliver F Wirz, Daniel Solis, Ramona A Hoh, Aihui Wang, Prabhu S Arunachalam, Deana Colburg, Shuchun Zhao, Emily Haraguchi, Alexandra S Lee, Mihir M Shah, Monali Manohar, Iris Chang, Fei Gao, Vamsee Mallajosyula, Chunfeng Li, James Liu, Massa J Shoura, Sayantani B Sindher, Ella Parsons, Naranjargal J Dashdorj, Naranbaatar D Dashdorj, Robert Monroe, Geidy E Serrano, Thomas G Beach, R Sharon Chinthrajah, Gregory W Charville, James L Wilbur, Jacob N Wohlstadter, Mark M Davis, Bali Pulendran, Megan L Troxell, George B Sigal, Yasodha Natkunam, Benjamin A Pinsky, Kari C Nadeau, Scott D Boyd
发表日期
2022/3/17
期刊
Cell
卷号
185
期号
6
页码范围
1025-1040. e14
出版商
Elsevier
简介
During the SARS-CoV-2 pandemic, novel and traditional vaccine strategies have been deployed globally. We investigated whether antibodies stimulated by mRNA vaccination (BNT162b2), including third-dose boosting, differ from those generated by infection or adenoviral (ChAdOx1-S and Gam-COVID-Vac) or inactivated viral (BBIBP-CorV) vaccines. We analyzed human lymph nodes after infection or mRNA vaccination for correlates of serological differences. Antibody breadth against viral variants is lower after infection compared with all vaccines evaluated but improves over several months. Viral variant infection elicits variant-specific antibodies, but prior mRNA vaccination imprints serological responses toward Wuhan-Hu-1 rather than variant antigens. In contrast to disrupted germinal centers (GCs) in lymph nodes during infection, mRNA vaccination stimulates robust GCs containing vaccine mRNA and spike …
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