作者
Silke C Mueller, Jolanta Majcher-Peszynska, Ralf G Mundkowski, Bernhard Uehleke, Sebastian Klammt, Hartwig Sievers, Romanus Lehnfeld, Bruno Frank, Kerstin Thurow, Guenther Kundt, Bernd Drewelow
发表日期
2009/1
期刊
European journal of clinical pharmacology
卷号
65
页码范围
81-87
出版商
Springer-Verlag
简介
Objective
Induction of CYP3A by St. John’s wort (SJW) products with high hyperforin content is well described. Since CYP3A induction is mediated by hyperforin in a concentration-dependent manner, and SJW preparations differ significantly in hyperforin content, the aim of the study was to evaluate the effect of an SJW powder with low hyperforin content on CYP3A function.
Methods
Twenty healthy male volunteers received an SJW powder with low hyperforin content for 2 weeks. Midazolam plasma concentration time profiles were characterized after a single oral dose of 7.5 mg midazolam on the day before and on the 14th day of SJW medication.
Results
Midazolam AUC0–∞ slightly decreased from 124.0 ± 62.5 ng/ml·h at baseline to 105.6 ± 53.2 ng/ml·h after SJW (P < 0.05), representing a mean 11.3% decrease (95 …
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SC Mueller, J Majcher-Peszynska, RG Mundkowski… - European journal of clinical pharmacology, 2009