作者
Michael V Holmes, Folkert W Asselbergs, Tom M Palmer, Fotios Drenos, Matthew B Lanktree, Christopher P Nelson, Caroline E Dale, Sandosh Padmanabhan, Chris Finan, Daniel I Swerdlow, Vinicius Tragante, Erik PA Van Iperen, Suthesh Sivapalaratnam, Sonia Shah, Clara C Elbers, Tina Shah, Jorgen Engmann, Claudia Giambartolomei, Jon White, Delilah Zabaneh, Reecha Sofat, Stela McLachlan, UCLEB consortium, Pieter A Doevendans, Anthony J Balmforth, Alistair S Hall, Kari E North, Berta Almoguera, Ron C Hoogeveen, Mary Cushman, Myriam Fornage, Sanjay R Patel, Susan Redline, David S Siscovick, Michael Y Tsai, Konrad J Karczewski, Marten H Hofker, W Monique Verschuren, Michiel L Bots, Yvonne T van der Schouw, Olle Melander, Anna F Dominiczak, Richard Morris, Yoav Ben-Shlomo, Jackie Price, Meena Kumari, Jens Baumert, Annette Peters, Barbara Thorand, Wolfgang Koenig, Tom R Gaunt, Steve E Humphries, Robert Clarke, Hugh Watkins, Martin Farrall, James G Wilson, Stephen S Rich, Paul IW de Bakker, Leslie A Lange, George Davey Smith, Alex P Reiner, Philippa J Talmud, Mika Kivimäki, Debbie A Lawlor, Frank Dudbridge, Nilesh J Samani, Brendan J Keating, Aroon D Hingorani, Juan P Casas
发表日期
2015/3/1
期刊
European heart journal
卷号
36
期号
9
页码范围
539-550
出版商
Oxford University Press
简介
Aims
To investigate the causal role of high-density lipoprotein cholesterol (HDL-C) and triglycerides in coronary heart disease (CHD) using multiple instrumental variables for Mendelian randomization.
Methods and results
We developed weighted allele scores based on single nucleotide polymorphisms (SNPs) with established associations with HDL-C, triglycerides, and low-density lipoprotein cholesterol (LDL-C). For each trait, we constructed two scores. The first was unrestricted, including all independent SNPs associated with the lipid trait identified from a prior meta-analysis (threshold P < 2 × 10−6); and the second a restricted score, filtered to remove any SNPs also associated with either of the other two lipid traits at P ≤ 0.01. Mendelian randomization meta-analyses were conducted in 17 studies including 62,199 participants and 12,099 CHD events. Both the unrestricted …
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MV Holmes, FW Asselbergs, TM Palmer, F Drenos… - European heart journal, 2015