作者
Guillermo J Tearney, Hiroshi Yabushita, Stuart L Houser, H Thomas Aretz, Ik-Kyung Jang, Kelly H Schlendorf, Christopher R Kauffman, Milen Shishkov, Elkan F Halpern, Brett E Bouma
发表日期
2003/1/7
期刊
Circulation
卷号
107
期号
1
页码范围
113-119
出版商
Lippincott Williams & Wilkins
简介
Background— Macrophage degradation of fibrous cap matrix is an important contributor to atherosclerotic plaque instability. An imaging technology capable of identifying macrophages in patients could provide valuable information for assessing plaque vulnerability. Optical coherence tomography (OCT) is a new intravascular imaging modality that allows cross-sectional imaging of tissue with a resolution of ≈10 μm. The aim of this study was to investigate the use of OCT for identifying macrophages in fibrous caps.
Methods and Results— OCT images of 26 lipid-rich atherosclerotic arterial segments obtained at autopsy were correlated with histology. Cap macrophage density was quantified morphometrically by immunoperoxidase staining with CD68 and smooth muscle actin and compared with the standard deviation of the OCT signal intensity at corresponding locations. There was a high degree of positive …
引用总数
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GJ Tearney, H Yabushita, SL Houser, HT Aretz, IK Jang… - Circulation, 2003