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Hand pose estimation from single depth images is an essential topic in computer vision and human computer interaction. Despite recent advancements in this area promoted by convolutional neural networks, accurate hand pose estimation is still a challenging problem. In this paper we propose a novel approach named as pose guided structured region ensemble network (Pose-REN) to boost the performance of hand pose estimation. Under the guidance of an initially estimated pose, the proposed method extracts regions from the feature maps of convolutional neural network and generates more optimal and representative features for hand pose estimation. The extracted feature regions are then integrated hierarchically according to the topology of hand joints by tree-structured fully connections to regress the refined hand pose. The final hand pose is obtained by an iterative cascaded method. Comprehensive …