作者
Vikrant V Sahasrabuddhe, Philip E Castle, Stephen Follansbee, Sylvia Borgonovo, Diane Tokugawa, Lauren M Schwartz, Thomas S Lorey, Brandon J LaMere, Julia C Gage, Barbara Fetterman, Sean Boyle, Mark Sadorra, Scott Dahai Tang, Teresa M Darragh, Nicolas Wentzensen
发表日期
2013/2/1
期刊
The Journal of infectious diseases
卷号
207
期号
3
页码范围
392-401
出版商
Oxford University Press
简介
Background. The prevention of human papillomavirus (HPV)–induced anal cancer in high-risk populations such as human immunodeficiency virus (HIV)-infected men who have sex with men (MSM) remains an urgent priority, given rising incidence rates despite widespread antiretroviral therapy use.
Methods. HPV genotypes and anal disease prevalence, by cytology and histopathologic findings, were evaluated among 363 HIV-infected MSM. We modeled fractions of high-grade anal intraepithelial neoplasia (HGAIN) attributable to individual carcinogenic HPV genotypes and estimated the range of the proportion of HGAIN cases potentially preventable by prophylactic HPV vaccines.
Results. HPV16 was the most common genotype overall (26.4% of cases) and among HGAIN cases (55%). Prevalence of multiple (≥2) carcinogenic HPV …
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VV Sahasrabuddhe, PE Castle, S Follansbee… - The Journal of infectious diseases, 2013