作者
Paula Singmann, Doron Shem-Tov, Simone Wahl, Harald Grallert, Giovanni Fiorito, So-Youn Shin, Katharina Schramm, Petra Wolf, Sonja Kunze, Yael Baran, Simonetta Guarrera, Paolo Vineis, Vittorio Krogh, Salvatore Panico, Rosario Tumino, Anja Kretschmer, Christian Gieger, Annette Peters, Holger Prokisch, Caroline L Relton, Giuseppe Matullo, Thomas Illig, Melanie Waldenberger, Eran Halperin
发表日期
2015/12
期刊
Epigenetics & chromatin
卷号
8
页码范围
1-13
出版商
BioMed Central
简介
Background
Disease risk and incidence between males and females reveal differences, and sex is an important component of any investigation of the determinants of phenotypes or disease etiology. Further striking differences between men and women are known, for instance, at the metabolic level. The extent to which men and women vary at the level of the epigenome, however, is not well documented. DNA methylation is the best known epigenetic mechanism to date.
Results
In order to shed light on epigenetic differences, we compared autosomal DNA methylation levels between men and women in blood in a large prospective European cohort of 1799 subjects, and replicated our findings in three independent European cohorts. We identified and validated 1184 CpG sites to be differentially methylated between men and women and observed that …
学术搜索中的文章
P Singmann, D Shem-Tov, S Wahl, H Grallert, G Fiorito… - Epigenetics & chromatin, 2015