作者
Giovanni Fiorito, Saverio Caini, Domenico Palli, Benedetta Bendinelli, Calogero Saieva, Ilaria Ermini, Virginia Valentini, Melania Assedi, Piera Rizzolo, Daniela Ambrogetti, Laura Ottini, Giovanna Masala
发表日期
2021/10
期刊
Aging cell
卷号
20
期号
10
页码范围
e13439
简介
Several biomarkers of healthy aging have been proposed in recent years, including the epigenetic clocks, based on DNA methylation (DNAm) measures, which are getting increasingly accurate in predicting the individual biological age. The recently developed “next‐generation clock” DNAmGrimAge outperforms “first‐generation clocks” in predicting longevity and the onset of many age‐related pathological conditions and diseases. Additionally, the total number of stochastic epigenetic mutations (SEMs), also known as the epigenetic mutation load (EML), has been proposed as a complementary DNAm‐based biomarker of healthy aging. A fundamental biological property of epigenetic, and in particular DNAm modifications, is the potential reversibility of the effect, raising questions about the possible slowdown of epigenetic aging by modifying one's lifestyle. Here, we investigated whether improved dietary habits …
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