作者
Cathal McCrory, Giovanni Fiorito, Cliona Ni Cheallaigh, Silvia Polidoro, Piia Karisola, Harri Alenius, Richard Layte, Teresa Seeman, Paolo Vineis, Rose Anne Kenny
发表日期
2019/6/1
期刊
Psychoneuroendocrinology
卷号
104
页码范围
64-73
出版商
Pergamon
简介
Individuals of lower socio-economic position (SEP) carry a heavier burden of disease and morbidity and live shorter lives on average compared with their more advantaged counterparts. This has sparked research interest in the processes and mechanisms via which social adversity gets biologically embedded. The present study directly compares the empirical worth of two candidate mechanisms: Allostatic Load (AL) and the Epigenetic Clock(s) for advancing our understanding of embodiment using a sub-sample of 490 individuals from the Irish Longitudinal Study (TILDA) who were explicitly selected for this purpose based on their inter-generational life course social class trajectory. A battery of 14 biomarkers representing the activity of 4 different physiological systems: Immunological, Cardiovascular, Metabolic, and Renal was used to construct the AL score. Biomarkers were dichotomised into high and low risk …
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