作者
Giovanni Fiorito, Simonetta Guarrera, C Valle, Fulvio Ricceri, Alessia Russo, S Grioni, A Mattiello, Cornelia Di Gaetano, Fabio Rosa, F Modica, Licia Iacoviello, G Frasca, R Tumino, V Krogh, Salvatore Panico, Paolo Vineis, Carlotta Sacerdote, Giuseppe Matullo
发表日期
2014/5/1
期刊
Nutrition, Metabolism and Cardiovascular Diseases
卷号
24
期号
5
页码范围
483-488
出版商
Elsevier
简介
Background and aims
Several epidemiological studies highlighted the association between folate and B-vitamins low intake and cardiovascular diseases (CVD) risk. Contrasting results were reported on the relationship between folate intake and DNA-methylation. Folate and B-vitamins may modulate DNA-methylation of specific enzymes which are included in the One-Carbon Metabolism (OCM) and in the homocysteine (Hcy) pathways. The aim of the study was to evaluate whether DNA-methylation profiles of OCM and Hcy genes could modulate the myocardial infarction (MI) risk conferred by a low B-vitamins intake.
Methods and results
Study sample (206 MI cases and 206 matched controls) is a case-control study nested in the prospective EPIC cohort. Methylation levels of 33 candidate genes where extracted by the whole epigenome analysis (Illumina-HumanMethylation450K-BeadChip). We identified three …
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G Fiorito, S Guarrera, C Valle, F Ricceri, A Russo… - Nutrition, Metabolism and Cardiovascular Diseases, 2014