作者
Giovanni Fiorito, Silvia Polidoro, Pierre-Antoine Dugué, Mika Kivimaki, Erica Ponzi, Giuseppe Matullo, Simonetta Guarrera, Manuela B Assumma, Panagiotis Georgiadis, Soterios A Kyrtopoulos, Vittorio Krogh, Domenico Palli, Salvatore Panico, Carlotta Sacerdote, Rosario Tumino, Marc Chadeau-Hyam, Silvia Stringhini, Gianluca Severi, Allison M Hodge, Graham G Giles, Riccardo Marioni, Richard Karlsson Linnér, Aisling M O’Halloran, Rose A Kenny, Richard Layte, Laura Baglietto, Oliver Robinson, Cathal McCrory, Roger L Milne, Paolo Vineis
发表日期
2017/11/24
期刊
Scientific reports
卷号
7
期号
1
页码范围
16266
出版商
Nature Publishing Group UK
简介
Low socioeconomic status (SES) is associated with earlier onset of age-related chronic conditions and reduced life-expectancy, but the underlying biomolecular mechanisms remain unclear. Evidence of DNA-methylation differences by SES suggests a possible association of SES with epigenetic age acceleration (AA). We investigated the association of SES with AA in more than 5,000 individuals belonging to three independent prospective cohorts from Italy, Australia, and Ireland. Low SES was associated with greater AA (β = 0.99 years; 95% CI 0.39,1.59; p = 0.002; comparing extreme categories). The results were consistent across different SES indicators. The associations were only partially modulated by the unhealthy lifestyle habits of individuals with lower SES. Individuals who experienced life-course SES improvement had intermediate AA compared to extreme SES categories, suggesting reversibility of …
学术搜索中的文章
G Fiorito, S Polidoro, PA Dugué, M Kivimaki, E Ponzi… - Scientific reports, 2017