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The increasing availability of healthcare data requires accurate analysis of disease diagnosis, progression, and real-time monitoring to provide improved treatments to the patients. In this context, Machine Learning (ML) models are used to extract valuable features and insights from high-dimensional and heterogeneous healthcare data to detect different diseases and patient activities in a Smart Healthcare System (SHS). However, recent researches show that ML models used in different application domains are vulnerable to adversarial attacks. In this paper, we introduce a new type of adversarial attacks to exploit the ML classifiers used in a SHS. We consider an adversary who has partial knowledge of data distribution, SHS model, and ML algorithm to perform both targeted and untargeted attacks. Employing these adversarial capabilities, we manipulate medical device readings to alter patient status (disease …