作者
Carlo Fabris, Edmondo Falleti, Annarosa Cussigh, Davide Bitetto, Elisabetta Fontanini, Sara Bignulin, Sara Cmet, Ezio Fornasiere, Elisa Fumolo, Stefano Fangazio, Andrea Cerutti, Rosalba Minisini, Mario Pirisi, Pierluigi Toniutto
发表日期
2011/4/1
期刊
Journal of hepatology
卷号
54
期号
4
页码范围
716-722
出版商
Elsevier
简介
BACKGROUND & AIMS
A single nucleotide polymorphism (rs12979860 C/T) 3kb upstream of the interleukin 28B (IL-28B) gene was shown to be associated with hepatitis C clearance. We verified whether this association also translates into a different genotype distribution at the end of the disease trajectory.
METHODS
A RFLP-PCR technique was used to genotype 412 patients with cirrhosis due to hepatitis C (n=199), hepatitis B (n=75), alcohol (n=110), and other causes (n=28), of whom 256 underwent liver transplantation (OLT). Hepatocellular carcinoma (HCC) was demonstrated in the native liver of 85 OLT patients, 52 with viral cirrhosis, and 33 with non-viral cirrhosis respectively. A group of 292 patients (235 HCV and 57 HBV positive) with mild chronic hepatitis and 344 healthy subjects served as controls.
RESULTS
A significant difference (p=0.0005) was observed in IL-28B rs12979860 genotype frequencies …
学术搜索中的文章
C Fabris, E Falleti, A Cussigh, D Bitetto, E Fontanini… - Journal of hepatology, 2011