作者
Josine L Min, Gibran Hemani, Eilis Hannon, Koen F Dekkers, Juan Castillo-Fernandez, René Luijk, Elena Carnero-Montoro, Daniel J Lawson, Kimberley Burrows, Matthew Suderman, Andrew D Bretherick, Tom G Richardson, Johanna Klughammer, Valentina Iotchkova, Gemma Sharp, Ahmad Al Khleifat, Aleksey Shatunov, Alfredo Iacoangeli, Wendy L McArdle, Karen M Ho, Ashish Kumar, Cilla Söderhäll, Carolina Soriano-Tárraga, Eva Giralt-Steinhauer, Nabila Kazmi, Dan Mason, Allan F McRae, David L Corcoran, Karen Sugden, Silva Kasela, Alexia Cardona, Felix R Day, Giovanni Cugliari, Clara Viberti, Simonetta Guarrera, Michael Lerro, Richa Gupta, Sailalitha Bollepalli, Pooja Mandaviya, Yanni Zeng, Toni-Kim Clarke, Rosie M Walker, Vanessa Schmoll, Darina Czamara, Carlos Ruiz-Arenas, Faisal I Rezwan, Riccardo E Marioni, Tian Lin, Yvonne Awaloff, Marine Germain, Dylan Aïssi, Ramona Zwamborn, Kristel Van Eijk, Annelot Dekker, Jenny Van Dongen, Jouke-Jan Hottenga, Gonneke Willemsen, Cheng-Jian Xu, Guillermo Barturen, Francesc Català-Moll, Martin Kerick, Carol Wang, Phillip Melton, Hannah R Elliott, Jean Shin, Manon Bernard, Idil Yet, Melissa Smart, Tyler Gorrie-Stone, BIOS Consortium, Chris Shaw, Ammar Al Chalabi, Susan M Ring, Göran Pershagen, Erik Melén, Jordi Jiménez-Conde, Jaume Roquer, Deborah A Lawlor, John Wright, Nicholas G Martin, Grant W Montgomery, Terrie E Moffitt, Richie Poulton, Tõnu Esko, Lili Milani, Andres Metspalu, John RB Perry, Ken K Ong, Nicholas J Wareham, Giuseppe Matullo, Carlotta Sacerdote, Salvatore Panico, Avshalom Caspi, Louise Arseneault, France Gagnon, Miina Ollikainen, Jaakko Kaprio, Janine F Felix, Fernando Rivadeneira, Henning Tiemeier, Marinus H van IJzendoorn, André G Uitterlinden, Vincent WV Jaddoe, Chris Haley, Andrew M McIntosh, Kathryn L Evans, Alison Murray, Katri Räikkönen, Jari Lahti, Ellen A Nohr, Thorkild IA Sørensen, Torben Hansen, Camilla S Morgen, Elisabeth B Binder, Susanne Lucae, Juan Ramon Gonzalez, Mariona Bustamante, Jordi Sunyer, John W Holloway, Wilfried Karmaus, Hongmei Zhang, Ian J Deary, Naomi R Wray, John M Starr, Marian Beekman, Diana van Heemst, P Eline Slagboom, Pierre-Emmanuel Morange, David-Alexandre Trégouët, Jan H Veldink, Gareth E Davies, Eco JC de Geus, Dorret I Boomsma, Judith M Vonk, Bert Brunekreef, Gerard H Koppelman, Marta E Alarcón-Riquelme, Rae-Chi Huang, Craig E Pennell, Joyce van Meurs, M Arfan Ikram, Alun D Hughes, Therese Tillin, Nish Chaturvedi, Zdenka Pausova, Tomas Paus, Timothy D Spector, Meena Kumari, Leonard C Schalkwyk, Peter M Visscher
发表日期
2021/9
期刊
Nature genetics
卷号
53
期号
9
页码范围
1311-1321
出版商
Nature Publishing Group US
简介
Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to understand mechanisms underpinning gene regulation and disease. In the present study, we describe results of DNAm quantitative trait locus (mQTL) analyses on 32,851 participants, identifying genetic variants associated with DNAm at 420,509 DNAm sites in blood. We present a database of >270,000 independent mQTLs, of which 8.5% comprise long-range (trans) associations. Identified mQTL associations explain 15–17% of the additive genetic variance of DNAm. We show that the genetic architecture of DNAm levels is highly polygenic. Using shared genetic control between distal DNAm sites, we constructed networks, identifying 405 discrete genomic communities enriched for genomic annotations and complex traits. Shared genetic variants are associated with both DNAm levels and complex diseases, but only in a …
学术搜索中的文章
JL Min, G Hemani, E Hannon, KF Dekkers… - Nature genetics, 2021